Two targeted treatment options for adults with generalized myasthenia gravis (gMG)
gMG is a rare, chronic, autoimmune disorder that can weaken muscles throughout the entire body.
Everyone experiences the symptoms of gMG differently.
While most people have fluctuating muscle weakness and fatigue, these symptoms vary from person to person and can range from mild to severe. gMG symptoms can make a variety of activities like climbing stairs, chewing, brushing your teeth, and combing your hair very challenging.
What causes gMG?
The neuromuscular junction, or NMJ, is the place where nerves meet the muscles they control.
gMG is caused by harmful antibodies produced by your immune system that get in the way of signaling in the NMJ.
Many people with gMG have anti-acetylcholine receptor (AChR) antibodies. A small number have anti-muscle–specific tyrosine kinase (MuSK) antibodies.
Healthy NMJ
Signals are sent from nerves and received by muscles as part of normal muscle function and movement
The role of FcRn in gMG
Both anti-AChR and anti-MuSK antibodies may stay in your body longer than normal because of the protein FcRn, or neonatal Fc receptor.
Inside cells
FcRn can stop harmful antibodies from being broken down by your cells’ natural waste clearance system
NMJ impacted by gMG
These antibodies block signals in the NMJ, resulting in damage to muscle cells and the symptoms of gMG
The role of C5 in gMG
Anti-AChR antibodies also activate a part of your immune system called “complement,” including protein C5.
NMJ impacted by gMG
Harmful antibodies disrupt signals and activate the complement system, resulting in damage to muscle cells and the symptoms of gMG
Rethinking your
gMG treatment
If you’re struggling with poorly controlled gMG, share your challenges with your doctor to help them better understand your unique experience with this condition.
While some treatments can help ease symptoms, they may not all target any underlying causes of gMG.
If you’re not satisfied with your progress, ask your doctor if a targeted treatment may be right for you.
Find tips for a productive conversation in our Doctor Discussion Guide.
DID YOU KNOW?
Around
50%
of people with gMG
still have moderate-to-severe symptoms that limit their activities of daily living despite treatment with conventional therapies
More options. Targeted treatments.
UCB’s commitment to the gMG community.
No two people living with gMG are alike, and everyone responds to treatment differently. That’s why UCB is proud to offer two therapies for this rare condition. Each treatment option works differently and is administered differently.
UCB is committed to helping improve the lives of people with gMG. Having options helps you and your doctor choose a treatment that fits your goals and your lifestyle.
UCB OFFERS:
An FcRn blocker
Harmful antibodies that cause gMG may stay in your body longer because of FcRn (neonatal Fc receptor).
A C5 inhibitor
Harmful anti-AChR antibodies activate part of your immune system called "complement" which works to attack your muscle cells.
